Gab1 (phospho Tyr627) Antibody
Product Specifications
Background
The protein encoded by Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
2549
Swiss Prot
Q13480
Accession Number
NP_002030.2
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Gab1 (Phospho-Tyr627) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 627 (V-E-Y (p) -L-D) derived from Human Gab1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
110 kDa
Specificity
This antibody detects endogenous level of Gab1 only when phosphorylated at tyrosine 627.
Applications Notes
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Symbol
GAB1
NCBI Official Name
GRB2-associated binding protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Anders Kallin, et al. (2004) J. Biol. Chem ; 279: 17897 - 17904. Hideto Kameda, et al. (2001) Cell Growth Differ ; 12: 307. Masaki Osawa, et al. (2002) J. Cell Biol ; 158: 773.
Other Product Names
ADDA, Growth factor receptor bound protein 2-associated protein 1
Tested Applications
WB, IF
Protein ID
46370073
Physical Properties
Liquid
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