A Synuclein (phospho Tyr136) Antibody
Product Specifications
Background
May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies) . Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
NCBI Gene ID
6622
Swiss Prot
P37840
Accession Number
NP_000336.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A-Synuclein (Phospho-Tyr136) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 136 (Q-D-Y (p) -E-P) derived from Human α -Synuclein.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific, Neuroscience
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
18 kDa
Specificity
This antibody detects endogenous level ofα -Synuclein only when phosphorylated at tyrosine 136.
Applications Notes
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Symbol
SNCA
NCBI Official Name
Synuclein, alpha (non A4 component of amyloid precursor)
NCBI Organism
Homo sapiens
Background Reference 01
Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43) : 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14) : 12334-42Negro A, et al. FASEB J 2002 Feb; 16 (2) : 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.
Other Product Names
PD1, NACP, PARK1, PARK4, FAK, FAK1, SYN, SYUA
Tested Applications
WB, IF
Protein ID
4507109
Physical Properties
Liquid
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