Synapsin (phospho Ser9) Antibody

Product Specifications

Background

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.

NCBI Gene ID

6853

Swiss Prot

P17600

Accession Number

NP_008881.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synapsin (Phospho-Ser9) antibody was raised against a peptide sequence around phosphorylation site of serine 9 (R-L-S (p) -D-S) derived from Human SYN1/synapsin.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific, Neuroscience

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

77 kDa

Specificity

This antibody detects endogenous level of synapsin only when phosphorylated at serine 9.

Applications Notes

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Symbol

SYN1

NCBI Official Name

Synapsin I

NCBI Organism

Homo sapiens

Background Reference 01

Diviya Sinha, et, al. (2005) Am J Physiol Renal Physiol ; 288: F703 - F713. Franco Onofri, et, al. (2000) J. Biol. Chem ; 275: 29857. Dario Bonanomi, et, al. (2005) J. Neurosci; 25: 7299 - 7308. Hiroshi Tokumitsu, et, al. (2005) J. Biol. Chem ; 280: 35108 - 35118.