GluR1 (phospho Ser849) Antibody

Product Specifications

Background

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

2890

Swiss Prot

P42261

Accession Number

NP_000818.2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

GluR1 (phospho-Ser849) antibody was raised against a peptide sequence around phosphorylation site of serine 849 (Q-Q-S (p) -I-N) derived from Human GluR1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Phospho-Specific, Neuroscience

Purification

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

Phospho-Specific

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Calculated Molecular Weight

110 kDa

Specificity

This antibody detects endogenous level of GluR1 only when phosphorylated at serine 849.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

GRIA1

NCBI Official Name

Glutamate receptor, ionotropic, AMPA 1

NCBI Organism

Homo sapiens

Background Reference 01

Emamian ES, et al. (2004) J Neurosci. 24 (7) : 1561-4Palmer, C. L. et al. (2005) Pharmacol. Rev. 57, 253-277.

Other Product Names

GLUH1, GLUR1, GLURA, GluA1, HBGR1, Mtapt, Tau, GLR1, GLUH1, GRIA1, GluR-1, GluR-A

Tested Applications

Protein ID

167001419

Physical Properties

Liquid

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