C Kit (phospho Tyr721) Antibody
Product Specifications
Background
This is the receptor for stem cell factor (mast cell growth factor) . It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K)
NCBI Gene ID
3815
Swiss Prot
P10721
Accession Number
NP_000213.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
C-Kit (Phospho-Tyr721) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 721 (N-E-Y (p) -M-D) derived from Human c-Kit.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
145 kDa
Specificity
This antibody detects endogenous level of c-Kit only when phosphorylated at tyrosine 721.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
KIT
NCBI Official Name
V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
NCBI Organism
Homo sapiens
Background Reference 01
Nocka, K. et al. (1990) EMBO J. 9, 1805-1813. Hirota, S. et al. (1998) Science 279, 577-580. Blume-Jensen, P. et al. (2000) Nat. Genet. 24, 157-162. Sattler, M. et al. (1997) J. Biol. Chem. 272, 10248-10253. Gommerman, J. L. et al. (1997) J. Biol. Chem. 272, 30519-30525.
Other Product Names
PBT, SCFR, C-Kit, CD117, CTNNG, DP3
Tested Applications
WB
Protein ID
4557695
Physical Properties
Liquid
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