Vinculin Antibody (biotin)

Product Specifications

Background

Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1) . Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2) . Expression of vinculin were shown to be affected by the level of actin expression (2,3) . Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4) . Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5) .

NCBI Gene ID

7414

Swiss Prot

P18206

Accession Number

NP_003364

Host

Rabbit

Reactivity

Human, Mouse, Rat, Rabbit, Chicken

Immunogen

Biotin-Vinculin antibody was raised against a 23 amino acid peptide near the amino terminus of human Vinculin.

Clonality

Polyclonal

Conjugation

Biotin

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

Biotin-Vinculin antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Buffer

Biotin-Vinculin Antibody is supplied in PBS containing 1% BSA and 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Biotin-Vinculin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

Biotin-Vinculin antibody is human, mouse, rat, rabbit and chicken reactive. At least three isoforms of Vinculin are known to exist.

Symbol

VCL

NCBI Official Name

Vinculin

NCBI Organism

Homo sapiens

Background Reference 01

Burridge et al. Annu. Rev. Cell Biol.1988; 4:487-525.

Background Reference 02

Gilmore et al. J. Cell Sci. 1992; 103:719-31.

Background Reference 03

Deakin et al. PLoS One 2012; 7:e37990.

Background Reference 04

Goldmann et al. Cell Biol. Int. 2013; Feb 1.

Other Product Names

CMD1W, CMH15, Metavinculin, MVCL

Tested Applications

ELISA, WB

Protein ID

4507877

Physical Properties

Liquid

Available Sizes

Curated Selection

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