LPAM-1 Antibody [DATK32] (APC)
Product Specifications
Background
The DATK32 monoclonal antibody specifically reacts with an epitoPEof the Mousealpha4beta7 integrin (LPAM-1) . The two subunits of the LPAM-1 heterodimer are the 154 kDa alpha4 and the 130 kDa beta7. Most mature lymphocytes, a subset of bone marrow cells, and some of the thymic cells express the alpha4beta7 integrin heterodimer. alpha4beta7 enhances the transendothelial migration of lymphocytes, and interacts with several ligands (fibronectin, CD106, and MAdCAM-1) . The interaction of DATK32 with the alpha4beta7 induces the alpha4beta7-dependent lymphocyte aggregation and inhibits LPAM-1-dediated cell adhesion.
NCBI Gene ID
16401
Swiss Prot
Q00651
Host
Mouse
Reactivity
Mouse
Clonality
Monoclonal
Clone
DATK32
Conjugation
APC
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
MouseIgG2a, kappa
Specificity
The DATK32 monoclonal antibody specifically reacts with an epitoPEof the Mousealpha4beta7 integrin (LPAM-1) .
Symbol
Itga4
NCBI Official Name
Integrin alpha 4
NCBI Organism
Mus musculus
Other Product Names
CD49D, Itga4B, Itga4
Tested Applications
Flow
Physical Properties
Liquid
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