KLRG1 Antibody [2F1] (APC)
Product Specifications
Background
The 2F1 monoclonal antibody is specific for the mouse Killer cell Lectin-like Receptor G1 (KLRG1), a homodimer consisting of two N-glycosylated subunits of 30-38 kDa, also known as MAFA (Mast cell Function-associated Antigen) . The antigen contains a cytoplasmic motif similar to ITIM (the immunoreceptor tyrosine-based inhibitory motif) . KLRG1 is a receptor for cadherin, a family of transmembrane glycoproteins that mediate cell adhesion, and a common marker of T cell senescence. The receptor is believed to play an important role in the innate and adaptive immune system through the regulation of leukocytes. It is expressed on lymphokine-activated killer (LAK) cells, adherent LAK (A-LAK) cells, a sub-set of natural killer (NK) cells, T cells. In NK cells, it inhibits cytokine production and cytotoxicity activity.The receptor expression was not detected on the mouse peritoneal mast cells, or bone marrow mast cells.
NCBI Gene ID
50928
Swiss Prot
O88713
Host
Hamster
Reactivity
Mouse
Clonality
Monoclonal
Clone
2F1
Conjugation
APC
Type
Primary Antibodies
Field of Research
Innate Immunity, Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Golden Syrian Hamster IgG
Specificity
The 2F1 monoclonal antibody is specific for the mouse Killer cell Lectin-like Receptor G1 (KLRG1), a homodimer consisting of two N-glycosylated subunits of 30-38 kDa, also known as MAFA (Mast cell Function-associated Antigen) .
Symbol
Klrg1
NCBI Official Name
Killer cell lectin-like receptor subfamily G, member 1
NCBI Organism
Mus musculus
Other Product Names
MAFA, 2F1-Ag, MAFA-L, Klrg1
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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