CD335 Antibody [29A1.4] (PE)

Product Specifications

Background

The 29A1.4 antibody specifically reacts with CD335 (NKp46), a 46kDA natural cytotoxicity receptor family molecule. It is expressed in only NK and a rare subset of NK-like T cells, not including the CD1d-restricted NKT division. CD335 is active during NK lysis of pathogen-infected and tumor cells.The 29A1.4 in vitro activates NK cells, but does not deplete NK cells in vivo.

NCBI Gene ID

17086

Swiss Prot

Q8C567

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

29A1.4

Conjugation

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2b, kappa

Specificity

The 29A1.4 antibody specifically reacts with CD335 (NKp46), a 46kDA natural cytotoxicity receptor family molecule.

Symbol

Ncr1

NCBI Official Name

Natural cytotoxicity triggering receptor 1

NCBI Organism

Mus musculus

Background Reference 01

Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T., ... Sakaguchi, S. (2005) . Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+ CD25+ CD4+ regulatory T cells.The Journal of experimental medicine,202 (7), 885-891.

Background Reference 02

Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., Sakaguchi, S. (2002) . Stimulation of CD25+ CD4+ regulatory T cells through GITR breaks immunological self-tolerance.Nature immunology,3 (2), 135-142.

Background Reference 03

Tone, M., Tone, Y., Adams, E., Yates, S. F., Frewin, M. R., Cobbold, S. P., Waldmann, H. (2003) . Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.Proceedings of the National Academy of Sciences,100 (25), 15059-15064.