CD289 Antibody [M9.D6] (FITC)

Product Specifications

Background

The M9.D6 monoclonal antibody specifically reacts with mouse CD289 also known as toll-like receptor 9 (TLR9) . CD289 is involved in the activation of innate immunity, in acquired immune responses, and autoimmune diseases. It is involved in the immune system’s response to unmethylated CpG dinucleotide sequences such as those found in bacterial, viral, or synthetic DNA. CD289 assists in pathogen recognition and is expressed by subtypes of dendritic cells and B cells.

NCBI Gene ID

81897

Swiss Prot

Q9EQU3

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

M9.D6

Conjugation

FITC

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2a

Specificity

The M9.D6 monoclonal antibody specifically reacts with mouse CD289 also known as toll-like receptor 9 (TLR9) .

Symbol

Tlr9

NCBI Official Name

Toll-like receptor 9

NCBI Organism

Mus musculus

Background Reference 01

Walzer, T., Blry, M., Chaix, J., Fuseri, N., Chasson, L., Robbins, S. H., ... Vivier, E. (2007) . Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46.Proceedings of the National Academy of Sciences,104 (9), 3384-3389.

Background Reference 02

Joncker, N. T., Fernandez, N. C., Treiner, E., Vivier, E., Raulet, D. H. (2009) . NK cell responsiveness is tuned commensurate with the number of inhibitory receptors for self-MHC class I: the rheostat model.The Journal of Immunology,182 (8), 4572-4580.

Background Reference 03

Gazit, R., Gruda, R., Elboim, M., Arnon, T. I., Katz, G., Achdout, H., ... Mandelboim, O. (2006) . Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1.Nature immunology,7 (5), 517-523.