CD278 Antibody [ISA-3] (PE-Cy7)

Product Specifications

Background

The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1. It is expressed on activated T cells and a group of thymocytes and is involved in the proliferation, activation, and cytokine production of T cells. When plate-bound, the ISA-3 antibody induces the production of IL-4,5,10 in T cells.

NCBI Gene ID

29851

Swiss Prot

Q9Y6W8

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

ISA-3

Conjugation

PE-Cy7

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1.

Symbol

ICOS

NCBI Official Name

Inducible T-cell co-stimulator

NCBI Organism

Homo sapiens

Background Reference 01

Latz, E., Schoenemeyer, A., Visintin, A., Fitzgerald, K. A., Monks, B. G., Knetter, C. F., ... Golenbock, D. T. (2004) . TLR9 signals after translocating from the ER to CpG DNA in the lysosome.Nature immunology,5 (2), 190-198.

Background Reference 02

Leifer, C. A., Kennedy, M. N., Mazzoni, A., Lee, C., Kruhlak, M. J., Segal, D. M. (2004) . TLR9 is localized in the endoplasmic reticulum prior to stimulation.The Journal of Immunology,173 (2), 1179-1183.

Background Reference 03

Jzsef, L., Khreiss, T., El Kebir, D., Filep, J. G. (2006) . Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils.The Journal of immunology,176 (2), 1195-1202.