CD278 Antibody [ISA-3] (PE)

Product Specifications

Background

The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1. It is expressed on activated T cells and a group of thymocytes and is involved in the proliferation, activation, and cytokine production of T cells. When plate-bound, the ISA-3 antibody induces the production of IL-4,5,10 in T cells.

NCBI Gene ID

29851

Swiss Prot

Q9Y6W8

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

ISA-3

Conjugation

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1.

Symbol

ICOS

NCBI Official Name

Inducible T-cell co-stimulator

NCBI Organism

Homo sapiens

Background Reference 01

Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., Kroczek, R. A. (1999) . ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.Nature,402, 21-24.

Background Reference 02

Quiroga, M. F., Pasquinelli, V., Martnez, G. J., Jurado, J. O., Zorrilla, L. C., Musella, R. M., ... Garca, V. E. (2006) . Inducible costimulator: a modulator of IFN- gammaproduction in human tuberculosis.The Journal of Immunology,176 (10), 5965-5974.

Background Reference 03

Buonfiglio, D., Bragardo, M., Redoglia, V., Vaschetto, R., Bottarel, F., Bonissoni, S., ... Dianzani, U. (2000) . The T cell activation molecule H4 and the CD28‐like molecule ICOS are identical.European journal of immunology,30 (12), 3463-3467.