CD278 Antibody [ISA-3] (PE)
Product Specifications
Background
The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1. It is expressed on activated T cells and a group of thymocytes and is involved in the proliferation, activation, and cytokine production of T cells. When plate-bound, the ISA-3 antibody induces the production of IL-4,5,10 in T cells.
NCBI Gene ID
29851
Swiss Prot
Q9Y6W8
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
ISA-3
Conjugation
PE
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-967
Fragment
Mouse IgG1, kappa
Specificity
The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1.
Symbol
ICOS
NCBI Official Name
Inducible T-cell co-stimulator
NCBI Organism
Homo sapiens
Background Reference 01
Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., Kroczek, R. A. (1999) . ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.Nature,402, 21-24.
Background Reference 02
Quiroga, M. F., Pasquinelli, V., Martnez, G. J., Jurado, J. O., Zorrilla, L. C., Musella, R. M., ... Garca, V. E. (2006) . Inducible costimulator: a modulator of IFN- gammaproduction in human tuberculosis.The Journal of Immunology,176 (10), 5965-5974.
Background Reference 03
Buonfiglio, D., Bragardo, M., Redoglia, V., Vaschetto, R., Bottarel, F., Bonissoni, S., ... Dianzani, U. (2000) . The T cell activation molecule H4 and the CD28‐like molecule ICOS are identical.European journal of immunology,30 (12), 3463-3467.
Other Product Names
AILIM, CD278, CVID1, ICOS
Tested Applications
Flow
Physical Properties
Liquid
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