CD284 Antibody [UT41] (PE)
Product Specifications
Background
The UT41 monoclonal antibody specifically reacts with mouse CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4) . The complex of TLR-4, MD-2, and CD14 regulates the innate immune system recognition of bacterial lipopolysaccharides (LPS) and is expressed on the surface of thioglycollate-elicited macrophages. The UT41 antibody can bind to TLR4 with or without the formation of the TLR4/MD-2 complex.
NCBI Gene ID
21898
Swiss Prot
Q9QUK6
Host
Mouse
Reactivity
Mouse
Clonality
Monoclonal
Clone
UT41
Conjugation
PE
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-966
Fragment
Mouse IgG1
Specificity
The UT41 monoclonal antibody specifically reacts with mouse CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4) .
Symbol
Tlr4
NCBI Official Name
Toll-like receptor 4
NCBI Organism
Mus musculus
Background Reference 01
Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., Kroczek, R. A. (1999) . ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.Nature,402, 21-24.
Background Reference 02
Quiroga, M. F., Pasquinelli, V., Martnez, G. J., Jurado, J. O., Zorrilla, L. C., Musella, R. M., ... Garca, V. E. (2006) . Inducible costimulator: a modulator of IFN- gammaproduction in human tuberculosis.The Journal of Immunology,176 (10), 5965-5974.
Background Reference 03
Buonfiglio, D., Bragardo, M., Redoglia, V., Vaschetto, R., Bottarel, F., Bonissoni, S., ... Dianzani, U. (2000) . The T cell activation molecule H4 and the CD28‐like molecule ICOS are identical.European journal of immunology,30 (12), 3463-3467.
Other Product Names
Lps, Ly87, Ran/M1, Rasl2-8, Tlr4 , Tlr4
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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