CD284 Antibody [HTA125] (PE)

Product Specifications

Background

The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4) . CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.

NCBI Gene ID

7099

Swiss Prot

O00206

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

HTA125

Conjugation

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG2a, kappa

Specificity

The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4) .

Symbol

TLR4

NCBI Official Name

Toll-like receptor 4

NCBI Organism

Homo sapiens

Background Reference 01

Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., Kroczek, R. A. (1999) . ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.Nature,402, 21-24.

Background Reference 02

Quiroga, M. F., Pasquinelli, V., Martnez, G. J., Jurado, J. O., Zorrilla, L. C., Musella, R. M., ... Garca, V. E. (2006) . Inducible costimulator: a modulator of IFN- gammaproduction in human tuberculosis.The Journal of Immunology,176 (10), 5965-5974.

Background Reference 03

Buonfiglio, D., Bragardo, M., Redoglia, V., Vaschetto, R., Bottarel, F., Bonissoni, S., ... Dianzani, U. (2000) . The T cell activation molecule H4 and the CD28‐like molecule ICOS are identical.European journal of immunology,30 (12), 3463-3467.