What is the catalog number for CD284 Antibody [HTA125] (PE)?

The catalog number for CD284 Antibody [HTA125] (PE) is 76-964.

What sizes are available for CD284 Antibody [HTA125] (PE)?

CD284 Antibody [HTA125] (PE) is available in the following size(s): 100 Tests.

Is CD284 Antibody [HTA125] (PE) in stock?

CD284 Antibody [HTA125] (PE) is currently made to order / not held in immediate stock. Contact us for lead time.

CD284 Antibody [HTA125] (PE)

Product Specifications

Background

The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4) . CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.

NCBI Gene ID

7099

Swiss Prot

O00206

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

HTA125

Conjugation

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG2a, kappa

Specificity

The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4) .

Symbol

TLR4

NCBI Official Name

Toll-like receptor 4

NCBI Organism

Homo sapiens

Background Reference 01

Yang, D., Liu, Y., Chen, Y., Jiao, D., Hou, X., Wang, L., Fu, N. (2012) . Pretreatment with Mycobacterium avium-derived lipids attenuates the response of murine macrophages to components of Mycobacterium tuberculosis.International journal of molecular medicine,29 (6), 1072.

Background Reference 02

Nomura, F., Akashi, S., Sakao, Y., Sato, S., Kawai, T., Matsumoto, M., ... Akira, S. (2000) . Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression.The Journal of Immunology,164 (7), 3476-3479.

Background Reference 03

Sato, S., Nomura, F., Kawai, T., Takeuchi, O., Mhlradt, P. F., Takeda, K., Akira, S. (2000) . Synergy and cross-tolerance between toll-like receptor (TLR) 2-and TLR4-mediated signaling pathways.The Journal of Immunology,165 (12), 7096-7101.