CD284 Antibody [HTA125] (PE)
Product Specifications
Background
The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4) . CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.
NCBI Gene ID
7099
Swiss Prot
O00206
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
HTA125
Conjugation
PE
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-964
Fragment
Mouse IgG2a, kappa
Specificity
The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4) .
Symbol
TLR4
NCBI Official Name
Toll-like receptor 4
NCBI Organism
Homo sapiens
Background Reference 01
Yang, D., Liu, Y., Chen, Y., Jiao, D., Hou, X., Wang, L., Fu, N. (2012) . Pretreatment with Mycobacterium avium-derived lipids attenuates the response of murine macrophages to components of Mycobacterium tuberculosis.International journal of molecular medicine,29 (6), 1072.
Background Reference 02
Nomura, F., Akashi, S., Sakao, Y., Sato, S., Kawai, T., Matsumoto, M., ... Akira, S. (2000) . Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression.The Journal of Immunology,164 (7), 3476-3479.
Background Reference 03
Sato, S., Nomura, F., Kawai, T., Takeuchi, O., Mhlradt, P. F., Takeda, K., Akira, S. (2000) . Synergy and cross-tolerance between toll-like receptor (TLR) 2-and TLR4-mediated signaling pathways.The Journal of Immunology,165 (12), 7096-7101.
Other Product Names
TOLL, CD284, TLR-4, ARMD10, TLR4
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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