CD274 Antibody [10F.9G2]
Product Specifications
Background
The 10F.9G2 monoclonal antibody specifically reacts with mouse CD274, also known as B7-H1 or PD-L1, a 43 kDa glycoprotein of the B7 family of the immunoglobulin superfamily. CD274 is expressed on the B and T lymphocytes, natural killer cells, and dendritic cells. The receptor for the B7-H1 molecule is PD-1, which contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), and is expressed on activated B and T cells. The interaction between CD274 and PD-1 seems to downregulate the T and B immune responses.
NCBI Gene ID
29126
Swiss Prot
Q9NZQ7
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
10F.9G2
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-957
Fragment
Rat IgG2b, kappa
Specificity
The 10F.9G2 monoclonal antibody specifically reacts with mouse CD274, also known as B7-H1 or PD-L1, a 43 kDa glycoprotein of the B7 family of the immunoglobulin superfamily.
Symbol
CD274
NCBI Official Name
CD274 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Paterson, A. M., Brown, K. E., Keir, M. E., Vanguri, V. K., Riella, L. V., Chandraker, A., ... Sharpe, A. H. (2011) . The programmed death-1 ligand 1: B7-1 pathway restrains diabetogenic effector T cells in vivo.The Journal of Immunology,187 (3), 1097-1105
Background Reference 02
Koehn, B. H., Ford, M. L., Ferrer, I. R., Borom, K., Gangappa, S., Kirk, A. D., Larsen, C. P. (2008) . PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue.The Journal of Immunology,181 (8), 5313-5322.
Background Reference 03
Maier, H., Isogawa, M., Freeman, G. J., Chisari, F. V. (2007) . PD-1: PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver.The Journal of Immunology,178 (5), 2714-2720.
Other Product Names
B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, CD274
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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