CD243 Antibody [UIC2] (PE)

Product Specifications

Background

The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp) . It is an ATP binding cassette (ABC) transport and is expressed on B, T, NK cells to the exclusion of monocytes. CD243 is involved in the process that transports molecules across the cellular membranes and plays a role in multidrug resistance. The UIC2 antibody inhibits CD243 mediated efflux.

NCBI Gene ID

5243

Swiss Prot

P08183

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

UIC2

Conjugation

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG2a

Specificity

The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp) .

Symbol

ABCB1

NCBI Official Name

ATP-binding cassette, sub-family B (MDR/TAP), member 1

NCBI Organism

Homo sapiens

Background Reference 01

Tseng, S. Y., Otsuji, M., Gorski, K., Huang, X., Slansky, J. E., Pai, S. I., ... Tsuchiya, H. (2001) . B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.The Journal of experimental medicine,193 (7), 839-846.

Background Reference 02

Wang, S., Bajorath, J., Flies, D. B., Dong, H., Honjo, T., Chen, L. (2003) . Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.The Journal of experimental medicine,197 (9), 1083-1091.

Background Reference 03

Aramaki, O., Shirasugi, N., Takayama, T., Shimazu, M., Kitajima, M., Ikeda, Y., ... Niimi, M. (2004) . Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen.Transplantation,77 (1), 6-12.