CD243 Antibody [UIC2] (PE)
Product Specifications
Background
The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp) . It is an ATP binding cassette (ABC) transport and is expressed on B, T, NK cells to the exclusion of monocytes. CD243 is involved in the process that transports molecules across the cellular membranes and plays a role in multidrug resistance. The UIC2 antibody inhibits CD243 mediated efflux.
NCBI Gene ID
5243
Swiss Prot
P08183
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
UIC2
Conjugation
PE
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-952
Fragment
Mouse IgG2a
Specificity
The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp) .
Symbol
ABCB1
NCBI Official Name
ATP-binding cassette, sub-family B (MDR/TAP), member 1
NCBI Organism
Homo sapiens
Background Reference 01
Tseng, S. Y., Otsuji, M., Gorski, K., Huang, X., Slansky, J. E., Pai, S. I., ... Tsuchiya, H. (2001) . B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.The Journal of experimental medicine,193 (7), 839-846.
Background Reference 02
Wang, S., Bajorath, J., Flies, D. B., Dong, H., Honjo, T., Chen, L. (2003) . Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.The Journal of experimental medicine,197 (9), 1083-1091.
Background Reference 03
Aramaki, O., Shirasugi, N., Takayama, T., Shimazu, M., Kitajima, M., Ikeda, Y., ... Niimi, M. (2004) . Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen.Transplantation,77 (1), 6-12.
Other Product Names
CLCS, MDR1, P-GP, PGY1, ABC20, CD243, GP170, ABCB1
Tested Applications
Flow
Physical Properties
Liquid
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