CD282 Antibody [TL2.1] (PE)
Product Specifications
Background
The TL2.1 monoclonal antibody specifically reacts with human CD282, the Toll-like receptor 2 (TLR2) . It is a type I transmembrane signaling receptor containing IL-1 receptor like intracellular domain and leucine-rich repeats (LRR) in the extracellular domain. CD282 is expressed on peripheral blood monocytes and is involved distinguishing bacterial lipoproteins. The TL2.1 antibody blocks the receptor and immunoprecipitates TLR2 from human mammary epithelial cells (HMEC) and peripheral blood mononuclear cells (PBMC) .
NCBI Gene ID
7097
Swiss Prot
O60603
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
TL2.1
Conjugation
PE
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Mouse IgG2a, kappa
Specificity
The TL2.1 monoclonal antibody specifically reacts with human CD282, the Toll-like receptor 2 (TLR2) .
Symbol
TLR2
NCBI Official Name
Toll-like receptor 2
NCBI Organism
Homo sapiens
Background Reference 01
Vinnakota, K., Hu, F., Ku, M. C., Georgieva, P. B., Szulzewsky, F., Pohlmann, A., ... Kettenmann, H. (2013) . Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.Neuro-oncology,15 (11), 1457-1468.
Background Reference 02
Meng, G., Rutz, M., Schiemann, M., Metzger, J., Grabiec, A., Schwandner, R., ... Kirschning, C. J. (2004) . Antagonistic antibody prevents toll-like receptor 2driven lethal shock-like syndromes.Journal of Clinical Investigation,113 (10), 1473-1481.
Other Product Names
TIL4, CD284, TLR2
Tested Applications
Flow
Physical Properties
Liquid
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
