CD272 Antibody [MIH26] (Biotin)

Product Specifications

Background

The MIH26 monoclonal antibody specifically reacts with human CD272, the human and B and T lymphocyte attenuator (BTLA) . It is expressed on macrophage, dendritic, NK, NKT, B, and T cells. CD272 (BTLA) is an inhibitory receptor that inhibits T cell proliferation after binding with its ligand, the herpes virus entry mediator (HVEM) . It is in the CD28-like family of receptors and is structurally similar to CTLA-4 and PD-1.

NCBI Gene ID

151888

Swiss Prot

Q7Z6A9

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

MIH26

Conjugation

Biotin

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG2a

Specificity

The MIH26 monoclonal antibody specifically reacts with human CD272, the human and B and T lymphocyte attenuator (BTLA) .

Symbol

BTLA

NCBI Official Name

B and T lymphocyte associated

NCBI Organism

Homo sapiens

Background Reference 01

Flo, T. H., Halaas, ., Lien, E., Ryan, L., Teti, G., Golenbock, D. T., ... Espevik, T. (2000) . Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.The Journal of Immunology,164 (4), 2064-2069.

Background Reference 02

Lien, E., Sellati, T. J., Yoshimura, A., Flo, T. H., Rawadi, G., Finberg, R. W., ... Golenbock, D. T. (1999) . Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.Journal of Biological Chemistry,274 (47), 33419-33425.

Background Reference 03

Cook, E. B., Stahl, J. L., Esnault, S., Barney, N. P., Graziano, F. M. (2005) . Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for