CD252 Antibody [RM134L] (APC)

Product Specifications

Background

The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells. On activated B cells it enhances immunoglobulin secretion and cell proliferation. CD252 is also known as the OX-40 ligand and interacts with the OX-40 antigen found on the surface of activated T cells. The RML134L is reported to block the costimulatory activity of OX-40L.

NCBI Gene ID

22164

Swiss Prot

P43488

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

RM134L

Conjugation

APC

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2b, kappa

Specificity

The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells.

Symbol

Tnfsf4

NCBI Official Name

Tumor necrosis factor (ligand) superfamily, member 4

NCBI Organism

Mus musculus

Background Reference 01

Otsuki, N., Kamimura, Y., Hashiguchi, M., Azuma, M. (2006) . Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells.Biochemical and biophysical research communications,344 (4), 1121-1127.

Background Reference 02

Watanabe, N., Gavrieli, M., Sedy, J. R., Yang, J., Fallarino, F., Loftin, S. K., ... Murphy, K. M. (2003) . BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.Nature immunology,4 (7), 670-679.

Background Reference 03

Sedy, J. R., Gavrieli, M., Potter, K. G., Hurchla, M. A., Lindsley, R. C., Hildner, K., ... Murphy, K. M. (2005) . B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator.Nature immunology,6 (1), 90-98.