CD197 Antibody [3D12] (FITC)

Product Specifications

Background

The 3D12 monoclonal antibody specifically reacts with human CD197 (CCR7 or EBI-1), a seven-transmembrane G-protein-coupled. It is the receptor for the secondary lymphoid-tissue chemokine (SLC or 6CKine), CCL19, and CCL21. CD197 is expressed on subsets of B and T cells, and mature dendritic cells. The monoclonal 3D12 antibody recognizes the N-terminus of the receptor.

NCBI Gene ID

1236

Swiss Prot

P32248

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

3D12

Conjugation

FITC

Type

Primary Antibodies

Field of Research

Immunology, Chemokines & Cytokines, Growth Factors

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The 3D12 monoclonal antibody specifically reacts with human CD197 (CCR7 or EBI-1), a seven-transmembrane G-protein-coupled.

Symbol

CCR7

NCBI Official Name

Chemokine (C-C motif) receptor 7

NCBI Organism

Homo sapiens

Background Reference 01

Sallusto, F., Lenig, D., Frster, R., Lipp, M., Lanzavecchia, A. (1999) . Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.Nature,401 (6754), 708-712.

Background Reference 02

Yoshida, R., Nagira, M., Imai, T., Baba, M., Takagi, S., Tabira, Y., ... Yoshie, O. (1998) . EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC.International immunology,10 (7), 901-910.

Background Reference 03

Lee, N., Llano, M., Carretero, M., Ishitani, A., Navarro, F., Lpez-Botet, M., Geraghty, D. E. (1998) . HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A.Proceedings of the National Academy of Sciences,95 (9), 5199-5204.