CD127 Antibody [A7R34] (APC)
Product Specifications
Background
The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the alpha subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels. Mature T cells express CD117 at low levels in the periphery.The A7R34 antibody prevents the interaction between IL-7 and its receptor and the binding of mAb SB/199, which also recognizes mouse CD127.
NCBI Gene ID
16197
Swiss Prot
P16872
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
A7R34
Conjugation
APC
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Rat IgG2a, kappa
Specificity
The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the alpha subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels.
Symbol
Il7r
NCBI Official Name
Interleukin 7 receptor
NCBI Organism
Mus musculus
Background Reference 01
Vudattu, N. K., Magalhaes, I., Schmidt, M., Seyfert-Margolis, V., Maeurer, M. J. (2007) . Reduced numbers of IL-7 receptor (CD127) expressing immune cells and IL-7-signaling defects in peripheral blood from patients with breast cancer. International journal of cancer,121 (7), 1512-1519.
Background Reference 02
Pandrau-Garcia, D., de Saint-Vis, B., Saeland, S., Renard, N., Ho, S., Moreau, I., ... Galizzi, J. P. (1994) . Growth inhibitory and agonistic signals of interleukin-7 (IL-7) can be mediated through the CDw127 IL-7 receptor.Blood,83 (12), 3613-3619.
Background Reference 03
Van Roon, J. A., Hartgring, S. A., van der Wurff-Jacobs, K. M., Bijlsma, J. W., Lafeber, F. P. (2010) . Numbers of CD25+ Foxp3+ T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients.Rheumatology,49 (11), 2084-2089.
Other Product Names
CD127, IL-7Ralpha, Il7r
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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