CD117 Antibody [ACK2] (APC)
Product Specifications
Background
The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene. The c-Kit receptor, also known as stem cell factor receptor, is expressed on hematopoietic progenitor cells in adult bone marrow, in progenitors of erythroid and myeloid lineages, and precursors of B and T cells. CD117 enhances the proliferation and the differentiation of the hematopoietic progenitor cells and seems to enhance the development of T cells, as the c-Kit receptor and its ligand are expressed by the thymus.
NCBI Gene ID
16590
Swiss Prot
P05532
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
ACK2
Conjugation
APC
Type
Primary Antibodies
Field of Research
Cancer
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-903
Fragment
Rat IgG2b, kappa
Specificity
The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene.
Symbol
Kit
NCBI Official Name
Kit oncogene
NCBI Organism
Mus musculus
Background Reference 01
Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.
Background Reference 02
Yarden, Y., Kuang, W. J., Yang-Feng, T., Coussens, L., Munemitsu, S., Dull, T. J., ... Ullrich, A. (1987) . Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.The EMBO Journal,6 (11), 3341.
Background Reference 03
Lerner, N. B., Nocka, K. H., Cole, S. R., Qiu, F. H., Strife, A., Ashman, L. K., Besmer, P. (1991) . Monoclonal antibody YB5. B8 identifies the human c-kit protein product.Blood,77 (9), 1876-1883.
Other Product Names
W, Bs, Fdc, Ssm, SCO1, SCO5, SOW3, CD117, c-KIT, Tr-kit, Gsfsco1, Gsfsco5, Gsfsow3, Kit
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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