CD117 Antibody [ACK2] (APC)

Product Specifications

Background

The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene. The c-Kit receptor, also known as stem cell factor receptor, is expressed on hematopoietic progenitor cells in adult bone marrow, in progenitors of erythroid and myeloid lineages, and precursors of B and T cells. CD117 enhances the proliferation and the differentiation of the hematopoietic progenitor cells and seems to enhance the development of T cells, as the c-Kit receptor and its ligand are expressed by the thymus.

NCBI Gene ID

16590

Swiss Prot

P05532

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

ACK2

Conjugation

APC

Type

Primary Antibodies

Field of Research

Cancer

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2b, kappa

Specificity

The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene.

Symbol

Kit

NCBI Official Name

Kit oncogene

NCBI Organism

Mus musculus

Background Reference 01

Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

Background Reference 02

Yarden, Y., Kuang, W. J., Yang-Feng, T., Coussens, L., Munemitsu, S., Dull, T. J., ... Ullrich, A. (1987) . Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.The EMBO Journal,6 (11), 3341.

Background Reference 03

Lerner, N. B., Nocka, K. H., Cole, S. R., Qiu, F. H., Strife, A., Ashman, L. K., Besmer, P. (1991) . Monoclonal antibody YB5. B8 identifies the human c-kit protein product.Blood,77 (9), 1876-1883.