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CD107a Antibody [H4A3] (APC)

Product Specifications

Background

The H4A3 monoclonal antibody specifically reacts with human CD107a, a heavily glycosylated type I membrane glycoprotein. CD107a is also known as Lysosomal-associated membrane protein 1 (LAMP-1) and is widely expressed intracellular antigen. It can be found on the surface of PHA-activated lymphocytes, activated platelets, cytotoxic T cells, NK cells, macrophages, epithelial cells, endothelial cells, and some tumor lines. CD107a is a ligand for E-selectin and galaptin and is reported to be involved in cell adhesion and tumor metastasis.

NCBI Gene ID

3916

Swiss Prot

P11279

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

H4A3

Conjugation

APC

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The H4A3 monoclonal antibody specifically reacts with human CD107a, a heavily glycosylated type I membrane glycoprotein.

Symbol

LAMP1

NCBI Official Name

Lysosomal-associated membrane protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Godfrey, D. I., Kennedy, J., Mombaerts, P., Tonegawa, S., Zlotnik, A. (1994) . Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8-thymocyte differentiation. The Journal of Immunology,152 (10), 4783-4792.

Background Reference 02

Godfrey, D. I., Zlotnik, A. L. B. E. R. T., Suda, T. A. K. A. S. H. I. (1992) . Phenotypic and functional characterization of c-kit expression during intrathymic T cell development.The Journal of Immunology,149 (7), 2281-2285.

Background Reference 03

Feng, H., Sandlow, J. I., Sandra, A. (1998) . The c-kit receptor and its possible signaling transduction pathway in mouse spermatozoa.Molecular reproduction and development,49 (3), 317-326.

Other Product Names

LAMPA, CD107a, LGP120, LAMP1

Tested Applications

Flow

Physical Properties

Liquid

Frequently Asked Questions

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