CD106 Antibody [STA] (PE)
Product Specifications
Background
The STA monoclonal antibody specifically reacts with human CD106, a 110 kDA glycoprotein also named Vascular Cell Adhesion Molecule-1 (VCAM-1) and INCAM-110. Its expression is induced by inflammation stimuli and cytokines and it is found mainly on activated vascular endothelium. CD106 is also found on subsets of macrophages, stromal cells, dendritic cells, and myeloid lineage cells. The integrins that bind CD106 are CD49d/CD29 and LPAM-1, and it is involved in cell adhesion, transmigration and T cell proliferation.
NCBI Gene ID
2022
Swiss Prot
P17813
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
STA
Conjugation
PE
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Mouse IgG1, kappa
Specificity
The STA monoclonal antibody specifically reacts with human CD106, a 110 kDA glycoprotein also named Vascular Cell Adhesion Molecule-1 (VCAM-1) and INCAM-110.
Symbol
ENG
NCBI Official Name
Endoglin
NCBI Organism
Homo sapiens
Background Reference 01
Elshal, M. F., Khan, S. S., Takahashi, Y., Solomon, M. A., McCoy, J. P. (2005) . CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood.Blood,106 (8), 2923-2924.
Background Reference 02
Shih, I. M. (1999) . The role of CD146 (Mel‐CAM) in biology and pathology.The Journal of pathology,189 (1), 4-11.
Background Reference 03
Solovey, A. N., Gui, L., Chang, L., Enenstein, J., Browne, P. V., Hebbel, R. P. (2001) . Identification and functional assessment of endothelial P1H12.Journal of Laboratory and Clinical Medicine,138 (5), 322-331.
Other Product Names
END, HHT1, ORW1, ENG
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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