CD115 Antibody [AFS98] (APC)

Product Specifications

Background

The AFS98 monoclonal antibody specifically reacts with the mouse CD115 molecule, a 150 kDa receptor for the colony stimulating factor (CSF-1) or macrophage CFS (M-CFS), expressed by some epithelial cells, monocytes, osteoclasts, and macrophages. The colony stimulating factor-1 regulates the proliferation and the differentiation of the monocytic lineage cells. The AFS98 antibody can be used to identify myeloid lineage cells.

NCBI Gene ID

12978

Swiss Prot

P09581

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

AFS98

Conjugation

APC

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2a, kappa

Specificity

Symbol

Csf1r

NCBI Official Name

Colony stimulating factor 1 receptor

NCBI Organism

Mus musculus

Background Reference 01

Schlossman, S. F. (1995) .Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press.

Background Reference 02

Wagner, B. J., Lindau, D., Ripper, D., Stierhof, Y. D., Glatzle, J., Witte, M., ... Knigsrainer, A. (2011) . Phagocytosis of dying tumor cells by human peritoneal mesothelial cells.Journal of cell science,124 (10), 1644-1654.

Background Reference 03

Leca, G., Mansur, S. E., Bensussan, A. (1995) . Expression of VCAM-1 (CD106) by a subset of TCR gamma delta-bearing lymphocyte clones. Involvement of a metalloprotease in the specific hydrolytic release of the soluble isoform.The Journal of Immunology,154 (3), 1069-1077.