CD144 Antibody [16B1] (PE)

Product Specifications

Background

The 16B1 monoclonal antibody specifically reacts with human CD144, the 140 kDA molecule called vascular endothelial (VE-cadherin) or cadherin 5. CD144 is an endothelial specific calcium-dependent adhesion molecule involved in cell contact-dependent growth inhibition, migration, survival, adhesion. It is concentrated at the intercellular boundaries of endothelial cells and essential in maintaining cell layer integrity.

NCBI Gene ID

1003

Swiss Prot

P33151

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

16B1

Conjugation

Type

Primary Antibodies

Field of Research

Cancer

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1

Specificity

The 16B1 monoclonal antibody specifically reacts with human CD144, the 140 kDA molecule called vascular endothelial (VE-cadherin) or cadherin 5.

Symbol

CDH5

NCBI Official Name

Cadherin 5, type 2 (vascular endothelium)

NCBI Organism

Homo sapiens

Background Reference 01

Corada, M., Mariotti, M., Thurston, G., Smith, K., Kunkel, R., Brockhaus, M., ... Dejana, E. (1999) . Vascular endothelialcadherin is an important determinant of microvascular integrity in vivo.Proceedings of the National Academy of Sciences,96 (17), 9815-9820.

Background Reference 02

Crosby, C. V., Fleming, P. A., Argraves, W. S., Corada, M., Zanetta, L., Dejana, E., Drake, C. J. (2005) . VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly.Blood,105 (7), 2771-2776.

Background Reference 03

May, C., Doody, J. F., Abdullah, R., Balderes, P., Xu, X., Chen, C. P., ... Bohlen, P. (2005) . Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature.Blood,105 (11), 4337-4344.