CD193 Antibody [5E8-G9-B4] (PE)

Product Specifications

Background

The 5E8-G9-B4 monoclonal antibody specifically reacts with human CD193, also known as CKR3 and CCR3. CD193. CD193 is a G protein-coupled seven transmembrane receptor that binds to eotaxin-1,2,3 and to a lesser degree to MCP-3,4 and RANTES. It is expressed on eosinophils and basophils, mast cells platelets, CD34+ hematopoietic progenitor, and mononuclear phagocytes. CD193 plays a role in asthma and is a co-receptor for HIV-1,2.

NCBI Gene ID

1232

Swiss Prot

P51677

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

5E8-G9-B4

Conjugation

Type

Primary Antibodies

Field of Research

Stem Cell, Chemokines & Cytokines, Growth Factors

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG2b, kappa

Specificity

The 5E8-G9-B4 monoclonal antibody specifically reacts with human CD193, also known as CKR3 and CCR3.

Symbol

CCR3

NCBI Official Name

Chemokine (C-C motif) receptor 3

NCBI Organism

Homo sapiens

Background Reference 01

Breviario, F., Caveda, L., Corada, M., Martin-Padura, I., Navarro, P., Golay, J., ... Dejana, E. (1995) . Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. Arteriosclerosis, thrombosis, and vascular biology,15 (8), 1229-1239.

Background Reference 02

Rajesh, D., Chinnasamy, N., Mitalipov, S. M., Wolf, D. P., Slukvin, I., Thomson, J. A., Shaaban, A. F. (2007) . Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.Stem Cells,25 (2), 490-499.

Background Reference 03

Dejana, E., Bazzoni, G., Lampugnani, M. G. (1999) . Vascular endothelial (VE) -cadherin: only an intercellular glue?.Experimental cell research,252 (1), 13-19.