CD123 Antibody [6H6] (PE)

Product Specifications

Background

The 6H6 monoclonal antibody specifically reacts with human CD123, the alpha chain subunit of the IL-3 receptor. CD123’s affinity to IL-3 is low, but increases when associated with CD131. It can be found on basophils, dendritic cells, macrophages, and mast cells.

NCBI Gene ID

3563

Swiss Prot

P26951

Host

Mouse

Reactivity

Human

Clonality

Monoclonal

Clone

6H6

Conjugation

Type

Primary Antibodies

Field of Research

Stem Cell, Chemokines & Cytokines, Growth Factors

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Mouse IgG1, kappa

Specificity

The 6H6 monoclonal antibody specifically reacts with human CD123, the alpha chain subunit of the IL-3 receptor.

Symbol

IL3RA

NCBI Official Name

Interleukin 3 receptor, alpha (low affinity)

NCBI Organism

Homo sapiens

Background Reference 01

Agrawal, L., Maxwell, C. R., Peters, P. J., Clapham, P. R., Liu, S. M., Mackay, C. R., Strayer, D. S. (2009) . Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microglia.Journal of General Virology,90 (3), 710-722.

Background Reference 02

Heath, H., Qin, S., Rao, P., Wu, L., LaRosa, G., Kassam, N., ... Mackay, C. R. (1997) . Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.Journal of Clinical Investigation,99 (2), 178.

Background Reference 03

Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P. D., ... Sodroski, J. (1996) . The -beta--chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.Cell,85 (7), 1135-1148.