CD152 Antibody [UC10-4F10-11] (APC)

Product Specifications

Background

The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.

NCBI Gene ID

12477

Swiss Prot

P09793

Host

Hamster

Reactivity

Mouse

Clonality

Monoclonal

Clone

UC10-4F10-11

Conjugation

APC

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Armenian Hamster IgG

Specificity

The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152.

Symbol

Ctla4

NCBI Official Name

Cytotoxic T-lymphocyte-associated protein 4

NCBI Organism

Mus musculus

Background Reference 01

Herling, M., Teitell, M. A., Shen, R. R., Medeiros, L. J., Jones, D. (2003) . TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin.Blood,101 (12), 5007-5009.

Background Reference 02

Peduzzi, E., Groeper, C., Schtte, D., Zajac, P., Rondini, S., Mensah-Quainoo, E., ... Daubenberger, C. A. (2007) . Local activation of the innate immune system in Buruli ulcer lesions.Journal of Investigative Dermatology,127 (3), 638-645.

Background Reference 03

Sun, Q., Woodcock, J. M., Rapoport, A., Stomski, F. C., Korpelainen, E. I., Bagley, C. J., ... Lopez, A. F. (1996) . Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist.Blood,87 (1), 83-92.