What is the catalog number for CD152 Antibody [UC10-4F10-11] (PE-Cy7)?

The catalog number for CD152 Antibody [UC10-4F10-11] (PE-Cy7) is 76-854.

What sizes are available for CD152 Antibody [UC10-4F10-11] (PE-Cy7)?

CD152 Antibody [UC10-4F10-11] (PE-Cy7) is available in the following size(s): 0.025 mg.

Is CD152 Antibody [UC10-4F10-11] (PE-Cy7) in stock?

CD152 Antibody [UC10-4F10-11] (PE-Cy7) is currently made to order / not held in immediate stock. Contact us for lead time.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

CD152 Antibody [UC10-4F10-11] (PE-Cy7)

Product Specifications

Background

The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.

NCBI Gene ID

12477

Swiss Prot

P09793

Host

Hamster

Reactivity

Mouse

Clonality

Monoclonal

Clone

UC10-4F10-11

Conjugation

PE-Cy7

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Armenian Hamster IgG

Specificity

The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152.

Symbol

Ctla4

NCBI Official Name

Cytotoxic T-lymphocyte-associated protein 4

NCBI Organism

Mus musculus

Background Reference 01

Alegre, M. L., Noel, P. J., Eisfelder, B. J., Chuang, E., Clark, M. R., Reiner, S. L., Thompson, C. B. (1996) . Regulation of surface and intracellular expression of CTLA4 on mouse T cells.The Journal of Immunology,157 (11), 4762-4770.

Background Reference 02

Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., ... Bluestone, J. A. (1994) . CTLA-4 can function as a negative regulator of T cell activation.Immunity,1 (5), 405-413.

Background Reference 03

Cilio, C. M., Daws, M. R., Malashicheva, A., Sentman, C. L., Holmberg, D. (1998) . Cytotoxic T Lymphocyte Antigen 4 Is Induced in the Thymus upon In Vivo Activation and Its Blockade Prevents Anti-CD3mediated Depletion of Thymocytes.The Journal of experimental medicine,188 (7), 1239-1246.