CD152 Antibody [UC10-4F10-11]
Product Specifications
Background
The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.
NCBI Gene ID
12477
Swiss Prot
P09793
Host
Hamster
Reactivity
Mouse
Clonality
Monoclonal
Clone
UC10-4F10-11
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C . Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-850
Fragment
Armenian Hamster IgG1, kappa
Specificity
The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152.
Symbol
Ctla4
NCBI Official Name
Cytotoxic T-lymphocyte-associated protein 4
NCBI Organism
Mus musculus
Background Reference 01
Alegre, M. L., Noel, P. J., Eisfelder, B. J., Chuang, E., Clark, M. R., Reiner, S. L., Thompson, C. B. (1996) . Regulation of surface and intracellular expression of CTLA4 on mouse T cells.The Journal of Immunology,157 (11), 4762-4770.
Background Reference 02
Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., ... Bluestone, J. A. (1994) . CTLA-4 can function as a negative regulator of T cell activation.Immunity,1 (5), 405-413.
Background Reference 03
Cilio, C. M., Daws, M. R., Malashicheva, A., Sentman, C. L., Holmberg, D. (1998) . Cytotoxic T Lymphocyte Antigen 4 Is Induced in the Thymus upon In Vivo Activation and Its Blockade Prevents Anti-CD3mediated Depletion of Thymocytes.The Journal of experimental medicine,188 (7), 1239-1246.
Other Product Names
Cd152, Ly-56, Ctla-4, Ctla4
Tested Applications
Flow
Physical Properties
Liquid
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