CD161 Antibody [HP-3G10] (PE)
Product Specifications
Background
The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A. CD161 is expressed on most natural killer cells, subsets of CD4+ and CD8+ T lymphocytes, gammadelta TCR T lymphocytes, a subset of CD3+ thymocytes, and especially on CD45RO+ T lymphocytes. Reports indicate that it may serve as a specific receptor for some natural killer cell targets and a possible stimulatory role.
NCBI Gene ID
3820
Swiss Prot
Q12918
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
HP-3G10
Conjugation
PE
Type
Primary Antibodies
Field of Research
Innate Immunity, Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-837
Fragment
Mouse IgG1, kappa
Specificity
The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A.
Symbol
KLRB1
NCBI Official Name
Killer cell lectin-like receptor subfamily B, member 1
NCBI Organism
Homo sapiens
Background Reference 01
Mrquez, C., Trigueros, C., Franco, J. M., Ramiro, A. R., Carrasco, Y. R., Lpez-Botet, M., Toribio, M. L. (1998) . Identification of a common developmental pathway for thymic natural killer cells and dendritic cells.Blood,91 (8), 2760-2771.
Background Reference 02
Cosmi, L., De Palma, R., Santarlasci, V., Maggi, L., Capone, M., Frosali, F., ... Annunziato, F. (2008) . Human interleukin 17producing cells originate from a CD161+ CD4+ T cell precursor.The Journal of experimental medicine,205 (8), 1903-1916.
Background Reference 03
Exley, M., Porcelli, S., Furman, M., Garcia, J., Balk, S. (1998) . CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant Valpha 24Jalpha Q T cell receptor alpha chains.The Journal of experimental medicine,188 (5), 867-876.
Other Product Names
NKR, CD161, CLEC5B, NKR-P1, NKRP1A, NKR-P1A, hNKR-P1A, KLRB1
Tested Applications
Flow
Physical Properties
Liquid
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