CD105 Antibody [MJ7/18] (PE)

Product Specifications

Background

The MJ7/18 monoclonal antibody specifically reacts with mouse CD105 (Endoglin), a 90kDA homodimeric glycoprotein expressed on vascular endothelial cells. CD105 is a marker for tumor angiogenesis research by identifying proliferating endothelium. It is also suggested to be involved in embryonic angiogenesis and cellular adhesion.

NCBI Gene ID

13805

Swiss Prot

Q63961

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

MJ7/18

Conjugation

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2a, kappa

Specificity

The MJ7/18 monoclonal antibody specifically reacts with mouse CD105 (Endoglin), a 90kDA homodimeric glycoprotein expressed on vascular endothelial cells.

Symbol

Eng

NCBI Official Name

Endoglin

NCBI Organism

Mus musculus

Background Reference 01

Ge, A. Z., Butcher, E. C. (1994) . Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF--beta- ligand.Gene,138 (1), 201-206.

Background Reference 02

Onoe, T., Ohdan, H., Tokita, D., Shishida, M., Tanaka, Y., Hara, H., ... Asahara, T. (2005) . Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice.The Journal of Immunology,175 (1), 139-146.

Background Reference 03

St-Jacques, S., Cymerman, U. R. S. Z. U. L. A., Pece, N. A. D. I. A., Letarte, M. (1994) . Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells.Endocrinology,134 (6), 2645-2657.