CD69 Antibody [H1.2F3] (APC)

Product Specifications

Background

The H1.2F3 monoclonal antibody specifically reacts with human CD69, the 27-33 kDA type II transmembrane protein also known as the very early activation antigen (VEA) or the activation inducer molecule (AIM) . It is expressed as a disulfide-linked dimer on B cells, T cells, NK cells, platelets, eosinophils, and neutrophils. It increases in expression upon cell activation and seems to serve a role as a signaling receptor.

NCBI Gene ID

12515

Swiss Prot

P37217

Host

Hamster

Reactivity

Mouse

Clonality

Monoclonal

Clone

H1.2F3

Conjugation

APC

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Armenian Hamster IgG

Specificity

Symbol

Cd69

NCBI Official Name

CD69 antigen

NCBI Organism

Mus musculus

Background Reference 01

Ge, A. Z., Butcher, E. C. (1994) . Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF--beta- ligand.Gene,138 (1), 201-206.

Background Reference 02

Onoe, T., Ohdan, H., Tokita, D., Shishida, M., Tanaka, Y., Hara, H., ... Asahara, T. (2005) . Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice.The Journal of Immunology,175 (1), 139-146.

Background Reference 03

St-Jacques, S., Cymerman, U. R. S. Z. U. L. A., Pece, N. A. D. I. A., Letarte, M. (1994) . Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells.Endocrinology,134 (6), 2645-2657.