CD69 Antibody [H1.2F3]

Product Specifications

Background

The H1.2F3 monoclonal antibody specifically reacts with human CD69, the 27-33 kDA type II transmembrane protein also known as the very early activation antigen (VEA) or the activation inducer molecule (AIM) . It is expressed as a disulfide-linked dimer on B cells, T cells, NK cells, platelets, eosinophils, and neutrophils. It increases in expression upon cell activation and seems to serve a role as a signaling receptor.

NCBI Gene ID

12515

Swiss Prot

P37217

Host

Hamster

Reactivity

Mouse

Clonality

Monoclonal

Clone

H1.2F3

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Armenian Hamster IgG

Specificity

Symbol

Cd69

NCBI Official Name

CD69 antigen

NCBI Organism

Mus musculus

Background Reference 01

Marzio, R., Jirillo, E., Ransijn, A., Mauel, J., Corradin, S. B. (1997) . Expression and function of the early activation antigen CD69 in murine macrophages.Journal of leukocyte biology,62 (3), 349-355.

Background Reference 02

Yokoyama, W. M., Koning, F., Kehn, P. J., Pereira, G. M., Stingl, G., Coligan, J. E., Shevach, E. M. (1988) . Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation.The Journal of Immunology,141 (2), 369-376.

Background Reference 03

Sobel, E. S., Yokoyama, W. M., Shevach, E. M., Eisenberg, R. A., Cohen, P. L. (1993) . Aberrant expression of the very early activation antigen on MRL/Mp-lpr/lpr lymphocytes.The Journal of Immunology,150 (2), 673-682.