CD49b Antibody [HMa2]

Product Specifications

Background

The HMa2 monoclonal antibody specifically reacts with mouse CD49b (integrin alpha 2), a 150kDA transmembrane glycoprotein that forms the VLA-2 complex with CD29 (integrin beta 1) . VLA-2 is expressed on NK-T cells, epithelial cells, platelets, and CD+4 T lymphocytes. It is the receptor for laminin and collagen and is upregulated in response to mitogens. The Hma2 antibody is reported to partially block the interaction with collagen in T cells, but not NK cells.

NCBI Gene ID

16398

Swiss Prot

Q62469

Host

Hamster

Reactivity

Mouse

Clonality

Monoclonal

Clone

HMa2

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Armenian Hamster IgG

Specificity

The HMa2 monoclonal antibody specifically reacts with mouse CD49b (integrin alpha 2), a 150kDA transmembrane glycoprotein that forms the VLA-2 complex with CD29 (integrin beta 1) .

Symbol

Itga2

NCBI Official Name

Integrin alpha 2

NCBI Organism

Mus musculus

Background Reference 01

Baron, J. L., Reich, E. P., Visintin, I., Janeway Jr, C. A. (1994) . The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1.Journal of Clinical Investigation,93 (4), 1700.

Background Reference 02

Chisholm, P. L., Williams, C. A., Lobb, R. R. (1993) . Monoclonal antibodies to the integrin alpha 4 subunit inhibit the murine contact hypersensitivity response.European journal of immunology,23 (3), 682-688.

Background Reference 03

Holzmann, B., McIntyre, B. W., Weissman, I. L. (1989) . Identification of a murine Peyer's patchspecific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4alpha .Cell,56 (1), 37-46.