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CD29 Antibody [HMb1-1] (PE)

Product Specifications

Background

The HMb1-1 monoclonal antibody specifically reacts with mouse/rat CD29, a 130 kDA molecule also known as integrin beta 1, GPIIa, and the VLA-beta chain. It is expressed broadly on endothelial cells, epithelial, leukocytes, and smooth muscle. CD29 forms the VLA 1-6 complexes through the non-covalent interaction with the alpha integrins of CD49 a-f. The HMb1-1 antibody is capable of inhibiting T cell proliferation and blocking cell adhesion.

NCBI Gene ID

16412;24511

Swiss Prot

P09055

Host

Hamster

Reactivity

Mouse, Rat

Clonality

Monoclonal

Clone

HMb1-1

Conjugation

PE

Type

Primary Antibodies

Field of Research

Cancer

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=76-796

Fragment

Armenian Hamster IgG

Specificity

The HMb1-1 monoclonal antibody specifically reacts with mouse/rat CD29, a 130 kDA molecule also known as integrin beta 1, GPIIa, and the VLA-beta chain.

Symbol

Itgb1

NCBI Official Name

Integrin beta 1 (fibronectin receptor beta)

NCBI Organism

Mus musculus; Rattus norvegicus

Background Reference 01

Ridger, V. C., Wagner, B. E., Wallace, W. A., Hellewell, P. G. (2001) . Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation.The Journal of Immunology,166 (5), 3484-3490.

Background Reference 02

Noto, K., Kato, K., Okumura, K., Yagita, H. (1995) . Identification and functional characterization of mouse CD29 with a mAb.International immunology,7 (5), 835-842.

Background Reference 03

Sangaletti, S., Di Carlo, E., Gariboldi, S., Miotti, S., Cappetti, B., Parenza, M., ... Colombo, M. P. (2008) . Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis.Cancer research,68 (21), 9050-9059.

Other Product Names

CD29, Fnrb, gpIIa, Gm9863, AA409975, AA960159, 4633401G24Rik, ENSMUSG00000051907, Itgb1

Tested Applications

Flow

Physical Properties

Liquid

Curated Selection

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