CD19 Antibody [1D3] (PE)
Product Specifications
Background
The 1D3 monoclonal antibody specifically reacts with mouse CD19, a 95 kDa transmembrane glycoprotein, a member of the Ig superfamily and a B cell-lineage differentiation antigen expressed by all the B lymphocyte development stages, except for the terminally differentiated plasma cells. CD19 associates with CD21, CD81 and MHC class II to form a multi-molecular complex that initiates the mature B lymphocyte activation by interaction with the B-cell receptors. CD 19 enhances the B cell proliferation, development and activation, and the maturation of memory B cells. In CD19-deficient mice, the generation and maturation of B lymphocytes in the bone marrow and periphery are affected.
NCBI Gene ID
12478
Swiss Prot
P25918
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Clone
1D3
Conjugation
PE
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-781
Fragment
Rat IgG2a, kappa
Specificity
The 1D3 monoclonal antibody specifically reacts with mouse CD19, a 95 kDa transmembrane glycoprotein, a member of the Ig superfamily and a B cell-lineage differentiation antigen expressed by all the B lymphocyte development stages, except for the terminally differentiated plasma cells.
Symbol
Cd19
NCBI Official Name
CD19 antigen
NCBI Organism
Mus musculus
Background Reference 01
Cherukuri, A., Cheng, P. C., Pierce, S. K. (2001) . The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens.The Journal of Immunology, 167 (1), 163-172.
Background Reference 02
Krop, I., De Fougerolles, A. R., Hardy, R. R., Allison, M., Schlissel, M. S., Fearon, D. T. (1996) . Self-renewal of B-1 lymphocytes is dependent on CD19.European journal of immunology,26 (1), 238-242.
Background Reference 03
Engel, P., Zhou, L. J., Ord, D. C., Sato, S., Koller, B., Tedder, T. F. (1995) . Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.Immunity,3 (1), 39-50.
Background Reference 04
Sato, S., Jansen, P. J., Tedder, T. F. (1997) . CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling.Proceedings of the National Academy of Sciences,94 (24), 13158-13162.
Other Product Names
AW495831, Cd19
Tested Applications
Flow
Physical Properties
Liquid
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