CD19 Antibody [HIB19] (APC)
Product Specifications
Background
The HIB19 monoclonal antibody reacts with a human 95 kDa transmembrane glycoprotein known as CD19, which is expressed by B lymphocytes during all the developmental stages, except for the terminally differentiated plasma cells. CD19 is also expressed on follicular dendritic cells, and seems to ensure the regulation of B lymphocytes proliferation. CD19, CD21, CD81, MHC class II, and Leu13 can bind together and form a complex which associates with the B cell receptor (BCR) on the surface of B lymphocytes and facilitates the signal transduction.
NCBI Gene ID
930
Swiss Prot
P15391
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
HIB19
Conjugation
APC
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-769
Fragment
Mouse IgG1, kappa
Specificity
The HIB19 monoclonal antibody reacts with a human 95 kDa transmembrane glycoprotein known as CD19, which is expressed by B lymphocytes during all the developmental stages, except for the terminally differentiated plasma cells.
Symbol
CD19
NCBI Official Name
CD19 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Cherukuri, A., Cheng, P. C., Pierce, S. K. (2001) . The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens.The Journal of Immunology, 167 (1), 163-172.
Background Reference 02
Krop, I., De Fougerolles, A. R., Hardy, R. R., Allison, M., Schlissel, M. S., Fearon, D. T. (1996) . Self-renewal of B-1 lymphocytes is dependent on CD19.European journal of immunology,26 (1), 238-242.
Background Reference 03
Engel, P., Zhou, L. J., Ord, D. C., Sato, S., Koller, B., Tedder, T. F. (1995) . Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.Immunity,3 (1), 39-50.
Background Reference 04
Sato, S., Jansen, P. J., Tedder, T. F. (1997) . CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling.Proceedings of the National Academy of Sciences,94 (24), 13158-13162.
Other Product Names
B4, CVID3, CD19
Tested Applications
Flow
Physical Properties
Liquid
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