CD48 Antibody [HM48-1]

Product Specifications

Background

The HM48-1 monoclonal antibody specifically reacts with mouse CD48, a GPI-anchored molecule in the Ig superfamily. CD48 was previously known as BCM1 in mice, Blast-1 in humans, and OX-45 in rats. Its ligands are CD2 and CD244 and it is expressed on leukocytes to the exclusion of non-hematopoietic cells. The utilization of the HM48-1 antibody has been reported to prolong cardiac allografts survival in in vivo studies. The antibody blocks the interaction of CD2 and CD244, inhibits CTL priming, and blocks the binding of soluble CD2 to CD48 expressing cells.

NCBI Gene ID

12506

Swiss Prot

P18181

Host

Hamster

Reactivity

Mouse

Clonality

Monoclonal

Clone

HM48-1

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity, Immunology, Stem Cell

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Armenian Hamster IgG

Specificity

The HM48-1 monoclonal antibody specifically reacts with mouse CD48, a GPI-anchored molecule in the Ig superfamily.

Symbol

Cd48

NCBI Official Name

CD48 antigen

NCBI Organism

Mus musculus

Background Reference 01

Kato, K., Koyanagi, M., Okada, H., Takanashi, T., Wong, Y. W., Williams, A. F., ... Yagita, H. (1992) . CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.The Journal of experimental medicine,176 (5), 1241-1249.

Background Reference 02

Qin, L., Chavin, K. D., Lin, J., Yagita, H., Bromberg, J. S. (1994) . Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival.The Journal of experimental medicine,179 (1), 341-346.

Background Reference 03

Chavin, K. D., Qin, L., Lin, J., Woodward, J., Baliga, P., Kato, K., ... Bromberg, J. S. (1994) . Anti-CD48 (murine CD2 ligand) mAbs suppress cell mediated immunity in vivo.International immunology,6 (5), 701-709.