CD38 Antibody [90]

Product Specifications

Background

The 90 monoclonal antibody specifically bind to mouse CD38, a type II transmembrane glycoprotein. CD38 is expressed on activated T cells, plasma cells, monocytes, and macrophages. In the mouse as opposed to the human, CD38 expression is downregulated on mouse germinal center B cells and plasma cells. CD38 displays cyclase and hydrolase enzymatic activity and is involved in lymphocyte adhesion, activation, and cell signaling. Its ligand is CD31.

NCBI Gene ID

12494

Swiss Prot

P56528

Host

Mouse

Reactivity

Mouse

Clonality

Monoclonal

Clone

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Other

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Mouse IgG2a, kappa

Specificity

The 90 monoclonal antibody specifically bind to mouse CD38, a type II transmembrane glycoprotein.

Symbol

Cd38

NCBI Official Name

CD38 antigen

NCBI Organism

Mus musculus

Background Reference 01

Gonzlez-lvaro, I., Domnguez-Jimnez, C., Ortiz, A. M., Nez-Gonzlez, V., Roda-Navarro, P., Fernndez-Ruiz, E., ... Snchez-Madrid, F. (2006) . Interleukin-15 and interferon- gammaparticipate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production.Arthritis research therapy,8 (4), R88.

Background Reference 02

Katagiri, T., Qi, Z., Ohtake, S., Nakao, S. (2011) . GPI‐anchored protein‐deficient T cells in patients with aplastic anemia and low‐risk myelodysplastic syndrome: implications for the immunopathophysiology of bone marrow failure.European journal of haematology,86 (3), 226-236.

Background Reference 03

Yokoyama, S., Staunton, D., Fisher, R., Amiot, M., Fortin, J. J., Thorley-Lawson, D. A. (1991) . Expression of the Blast-1 activation/adhesion molecule and its identification as CD48.The Journal of immunology,146 (7), 2192-2200.