CD28 Antibody [JJ319]

Product Specifications

Background

The JJ319 monoclonal antibody specifically reacts with rat CD28, a 44 kDa glycoprotein member of the immunoglobulin superfamily. CD28 is expressed on alpha/beta TCR+ T cells, some gamma/delta TCR+ T cells and a subset of NK cells. CD28 is a costimulatory receptor required for T cell activation. Its ligands are CD80 (B7-1) and CD86 (B7-2) .

NCBI Gene ID

25660

Swiss Prot

P31042

Host

Mouse

Reactivity

Rat

Clonality

Monoclonal

Clone

JJ319

Conjugation

Unconjugated

Type

Primary Antibodies, Functional Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C . Do not freeze.

Fragment

Mouse IgG1

Specificity

The JJ319 monoclonal antibody specifically reacts with rat CD28, a 44 kDa glycoprotein member of the immunoglobulin superfamily.

Symbol

Cd28

NCBI Official Name

Cd28 molecule

NCBI Organism

Rattus norvegicus

Background Reference 01

Nandi, D., Gross, J. A., Allison, J. P. (1994) . CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells.The Journal of Immunology,152 (7), 3361-3369.

Background Reference 02

Gross, J. A., Callas, E. L. E. N. I., Allison, J. P. (1992) . Identification and distribution of the costimulatory receptor CD28 in the mouse.The Journal of Immunology,149 (2), 380-388.

Background Reference 03

Nishio, M., Spielman, J., Lee, R. K., Nelson, D. L., Podack, E. R. (1996) . CD80 (B7. 1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis.The Journal of Immunology,157 (10), 4347-4353.