CD28 Antibody [CD28.2] (APC)
Product Specifications
Background
The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some subregions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.
NCBI Gene ID
920
Swiss Prot
P10747
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
CD28.2
Conjugation
APC
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=76-736
Fragment
Mouse IgG1, kappa
Specificity
The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes.
Symbol
CD28
NCBI Official Name
CD28 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Nandi, D., Gross, J. A., Allison, J. P. (1994) . CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells.The Journal of Immunology,152 (7), 3361-3369.
Background Reference 02
Gross, J. A., Callas, E. L. E. N. I., Allison, J. P. (1992) . Identification and distribution of the costimulatory receptor CD28 in the mouse.The Journal of Immunology,149 (2), 380-388.
Background Reference 03
Grossi, J. A., Raulet, D. H., Allison, J. P. (1992) . CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones.Nature,356, 607-9.
Background Reference 04
Nishio, M., Spielman, J., Lee, R. K., Nelson, D. L., Podack, E. R. (1996) . CD80 (B7. 1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis.The Journal of Immunology,157 (10), 4347-4353.
Other Product Names
Tp44, CD28
Tested Applications
Flow
Physical Properties
Liquid
Curated Selection
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