CD8b Antibody [H35-17.2] (APC)

Product Specifications

Background

The H35-17.2 monoclonal antibody specifically reacts the mouse cd8 beta, a 32 kDa chain also known as Ly-3 and Lyt-3. CD8 is a T cell surface antigen co-receptor that interacts with MHC class I molecules on antigen presenting cells. It is expressed as a heterodimer with the alpha cd8 chain. The H35-17.2 antibody blocks T cell-mediated cytolysis of allogeneic lymphoma cells.

NCBI Gene ID

12526

Swiss Prot

P10300

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

H35-17.2

Conjugation

APC

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2b, kappa

Specificity

The H35-17.2 monoclonal antibody specifically reacts the mouse cd8 beta, a 32 kDa chain also known as Ly-3 and Lyt-3.

Symbol

Cd8b1

NCBI Official Name

CD8 antigen, beta chain 1

NCBI Organism

Mus musculus

Background Reference 01

Driessens, M. H., Van Hulten, P., Zuurbier, A., La Riviere, G., Roos, E. (1996) . Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and-3 are distinct.Journal of leukocyte biology,60 (6), 758-765.

Background Reference 02

Zahalka, M. A., Naor, D. (1994) . -beta-2-lntegrin dependent aggregate formation between LB T cell lymphoma and spleen cells: assessment of correlation with spleen invasiveness.International immunology,6 (6), 917-924.

Background Reference 03

Isobe, M., Yagita, H., Okumura, K., Ihara, A. (1992) . Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1.Science,255 (5048), 1125-1127.