CD8b Antibody [H35-17.2] (PE)

Product Specifications

Background

The H35-17.2 monoclonal antibody specifically reacts the mouse cd8 beta, a 32 kDa chain also known as Ly-3 and Lyt-3. CD8 is a T cell surface antigen co-receptor that interacts with MHC class I molecules on antigen presenting cells. It is expressed as a heterodimer with the alpha cd8 chain. The H35-17.2 antibody blocks T cell-mediated cytolysis of allogeneic lymphoma cells.

NCBI Gene ID

12526

Swiss Prot

P10300

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

H35-17.2

Conjugation

Type

Primary Antibodies

Field of Research

Immunology

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Fragment

Rat IgG2b, kappa

Specificity

The H35-17.2 monoclonal antibody specifically reacts the mouse cd8 beta, a 32 kDa chain also known as Ly-3 and Lyt-3.

Symbol

Cd8b1

NCBI Official Name

CD8 antigen, beta chain 1

NCBI Organism

Mus musculus

Background Reference 01

Lefrancois, L. (1991) . Phenotypic complexity of intraepithelial lymphocytes of the small intestine.The Journal of Immunology,147 (6), 1746-1751.

Background Reference 02

Walker, I. D., Murray, B. J., Hogarth, P. M., Kelso, A., McKenzie, I. F. (1984) . Comparison of thymic and peripheral T cell Ly‐2/3 antigens.European journal of immunology,14 (10), 906-910.

Background Reference 03

THOMA-USZYNSKI, S., LADEL, C., KAUFMANN, S. (1997) . Abscess formation in Listeria monocytogenes-infected gamma-delta T cell deficient mouse mutants involves alpha -beta T cells.Microbial pathogenesis,22 (2), 123-128.