CD8a Antibody [RPA-T8] (APC-Cy7)

The RPA-T8 monoclonal antibody specifically reacts with the human CD8a molecule, a 32 kDa cell surface receptor expressed either as a heterodimer (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha) on the majority of thymocytes, a subpopulation of mature T cells, and natural killer cells. CD8 interacts with the major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells. The RPA-T8 antibody reacts with 13-48% of peripheral lymphocytes, 80% of thymocytes, and a subset of natural killer cells. RPA-T8, OKT8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitope or block each other by steric hindrance.

The RPA-T8 monoclonal antibody specifically reacts with the human CD8a molecule, a 32 kDa cell surface receptor expressed either as a heterodimer (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha) on the majority of thymocytes, a subpopulation of mature T cells, and natural killer cells.

Walker, I. D., Murray, B. J., Hogarth, P. M., Kelso, A., McKenzie, I. F. (1984) . Comparison of thymic and peripheral T cell Ly‐2/3 antigens.European journal of immunology,14 (10), 906-910.

THOMA-USZYNSKI, S., LADEL, C., KAUFMANN, S. (1997) . Abscess formation in Listeria monocytogenes-infected gamma-delta T cell deficient mouse mutants involves alpha -beta T cells.Microbial pathogenesis,22 (2), 123-128.