CD8a Antibody [OKT8] (FITC)
Product Specifications
Background
The OKT8 monoclonal antibody specifically reacts with human CD8alpha molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa. CD8alpha is a member of the Ig superfamily, expressed as a homodimer (CD8alphaalpha) or as a heterodimer (CD8alphabeta) . CD8+ alphabeta T lymphocytes express both CD8alphaalpha and CD8alphabeta, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes.OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.
NCBI Gene ID
925
Swiss Prot
P01732
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
OKT8
Conjugation
FITC
Type
Primary Antibodies
Field of Research
Immunology
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
MouseIgG2a
Specificity
The OKT8 monoclonal antibody specifically reacts with human CD8alpha molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa.
Symbol
CD8A
NCBI Official Name
CD8a molecule
NCBI Organism
Homo sapiens
Background Reference 01
Sayos, J., Wu, C., Morra, M., Wang, N., Zhang, X., Allen, D., ... Terhorst, C. (1998) . The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.Nature,395 (6701), 462-469.
Background Reference 02
Thomas, Y., Sosman, J., Irigoyen, O., Friedman, S. M., Kung, P. C., Goldstein, G., Chess, L. (1980) . Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative TT interactions in the immunoregulation of B cell differentiation.The Journal of Immunology,125 (6), 2402-2408.
Background Reference 03
Campanelli, R., Palermo, B., Garbelli, S., Mantovani, S., Lucchi, P., Necker, A., ... Giachino, C. (2002) . Human CD8 coreceptor is strictly involved in MHCpeptide tetramerTCR binding and T cell activation.International immunology,14 (1), 39-44.
Other Product Names
CD8, MAL, p32, Leu2, CD8A
Tested Applications
Flow
Physical Properties
Liquid
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